Klinefelter's syndrome and extragonadal germ cell tumors
نویسندگان
چکیده
منابع مشابه
Extragonadal germ cell tumors.
Germ cell cancer is the most common malignancy in men aged 15–35 years; 5% of the malignant germ cell tumors are of extragonadal origin [1]. An extragonadal germ cell tumor (EGGCT) is by definition a germ cell neoplasm displaying one of the histologies associated with gonadal origin, but located outside of the gonads. This specific clinical entity was first described in the 19th century [2, 3]....
متن کاملShould extragonadal germ cell tumors be included in studies of families with testicular germ cell tumors?
BACKGROUND Family history is among the few established risk factors for testicular germ cell tumor (TGCT). Approximately 1.4% of newly diagnosed TGCT patients report a positive family history of TGCT. Sons and siblings of TGCT patients have four- to six fold and eight- to tenfold increase in TGCT risk, respectively. In twins of men with TGCT the relative risk of testicular cancer is 37.5 (12.3-...
متن کاملMale Extragonadal Germ Cell Tumors of the Adult.
Male extragonadal germ cell tumors (EGCTs) are characterized by a malignant transformation of germ cells without the presence of a gonadal primary tumor. EGCTs represent up to 5% of all germ cell tumors (GCTs) with an incidence around 1/1,000,000. It is assumed that EGCTs either derive from a malignant transformation of germ cells that were misdirected during embryogenesis, or from germ cells t...
متن کاملKlinefelter Syndrome with Poor Risk Extragonadal Germ Cell Tumor
Germ cell tumors are the most common malignancy in men aged 15-35 years old, with a small percentage presenting in an extragonadal location. These tumors are seldom identified in the gastrointestinal tract. There is increased risk of extragonadal germ cell tumors (EGCT) in men with Klinefelter syndrome (KS). We report a rare case of a 37-year-old male with KS and EGCT discovered in the duodenum...
متن کاملProtocol for the examination of specimens from pediatric and adult patients with extragonadal germ cell tumors.
Authors Amy Heerema-McKenney, MD* Department of Pathology, Stanford University, Palo Alto, California Jay Bowen, MS Center for Childhood Cancer, Columbus Children’s Research Institute, Columbus, Ohio D. Ashley Hill, MD Department of Pathology, Children’s National Medical Center, Washington, DC Stephen J. Qualman, MD** Center for Childhood Cancer, Columbus Children’s Research Institute, Columbus...
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ژورنال
عنوان ژورنال: Cancer
سال: 1987
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19870901)60:5<1053::aid-cncr2820600520>3.0.co;2-1